Protein name:
WD repeat domain-containing protein 83 ;
Alternative:
Mitogen-activated protein kinase organizer 1 (MAPK organizer 1) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with EGLN3/PHD3. Identified in the spliceosome C complex (By similarity). Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1.
Function:
Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing.
Subcellular Location:
Cytoplasm
Nucleus
Predominantly cytoplasmic (By similarity). Partially nuclear.
Protein Attributes:
50:
MAFPEPKPRA | PELPQKRMKT | LDCSQGAVRA | VRFNVDGNYC | LTCGSDKTLK |
100:
LWNPLRGTLL | RTYSGHGYEV | LDAAGSFDNS | HLCSGGGDKT | VVLWDVATGQ |
150:
VVRKFRGHAG | KVNTVQFNEE | ATVILSGSID | SSVRCWDCRS | RKPEPVQTLD |
200:
EARDGISSVK | VSDHEILAGS | VDGRVRRYDL | RMGQVSSDYV | GSPITCTCFS |
250:
RDGQCTLISS | LDSTLRLLDK | DTGELLGEYV | GHKNQQYKLD | CCLSERDTHV |
300:
VSCSEDGKVF | FWDLVEGALA | LALPVGSNVV | QSLAYHPTEP | CLLTAMGGSI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Mouse WD repeat domain-containing protein 83
ELISA Kit for Mouse WD repeat domain-containing protein 83
ELISA Kit for Mouse WD repeat domain-containing protein 83
CLIA Kit for Mouse WD repeat domain-containing protein 83
CLIA Kit for Mouse WD repeat domain-containing protein 83
CLIA Kit for Mouse WD repeat domain-containing protein 83
Polyclonal Antibody for Mouse WD repeat domain-containing protein 83
Polyclonal Antibody for Mouse WD repeat domain-containing protein 83
Polyclonal Antibody for Mouse WD repeat domain-containing protein 83
Monoclonal Antibody for Mouse WD repeat domain-containing protein 83
Monoclonal Antibody for Mouse WD repeat domain-containing protein 83
Monoclonal Antibody for Mouse WD repeat domain-containing protein 83
Protein for Mouse WD repeat domain-containing protein 83
Protein for Mouse WD repeat domain-containing protein 83
Protein for Mouse WD repeat domain-containing protein 83
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH MAP2K1; MAP2K2; LAMTOR3; ARAF; MAPK1 AND MAPK3
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Testis .
tissue :
Urinary bladder .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
strain :
C57BL/6J .
strain :
Czech II .
strain :
FVB/N .
tissue :
Mammary gland .
tissue :
Mammary tumor .