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Index > Protein center > Wdr83(Gene name) > Mouse
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  • Wdr83 (Gene name),
  • WD repeat domain-containing protein 83 (Protein name ),  WDR83_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Wdr83(Morg1);
    Protein name:
    WD repeat domain-containing protein 83;
    Alternative:
    Mitogen-activated protein kinase organizer 1(MAPK organizer 1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with EGLN3/PHD3. Identified in the spliceosome C complex (By similarity). Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1.
    Function:
    Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing.
    Subcellular Location:
    Cytoplasm Nucleus Predominantly cytoplasmic (By similarity). Partially nuclear.
    Protein Attributes:
    Sequence length:
    315
    Sequence:
    50:
    MAFPEPKPRA | PELPQKRMKT | LDCSQGAVRA | VRFNVDGNYC | LTCGSDKTLK | 
    100:
    LWNPLRGTLL | RTYSGHGYEV | LDAAGSFDNS | HLCSGGGDKT | VVLWDVATGQ | 
    150:
    VVRKFRGHAG | KVNTVQFNEE | ATVILSGSID | SSVRCWDCRS | RKPEPVQTLD | 
    200:
    EARDGISSVK | VSDHEILAGS | VDGRVRRYDL | RMGQVSSDYV | GSPITCTCFS | 
    250:
    RDGQCTLISS | LDSTLRLLDK | DTGELLGEYV | GHKNQQYKLD | CCLSERDTHV | 
    300:
    VSCSEDGKVF | FWDLVEGALA | LALPVGSNVV | QSLAYHPTEP | CLLTAMGGSI | 
    315:
    QYWREETYEA | EGGAG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse WD repeat domain-containing protein 83
    ELISA Kit for Mouse WD repeat domain-containing protein 83
    ELISA Kit for Mouse WD repeat domain-containing protein 83
    CLIA Kit for Mouse WD repeat domain-containing protein 83
    CLIA Kit for Mouse WD repeat domain-containing protein 83
    CLIA Kit for Mouse WD repeat domain-containing protein 83
    Polyclonal Antibody for Mouse WD repeat domain-containing protein 83
    Polyclonal Antibody for Mouse WD repeat domain-containing protein 83
    Polyclonal Antibody for Mouse WD repeat domain-containing protein 83
    Monoclonal Antibody for Mouse WD repeat domain-containing protein 83
    Monoclonal Antibody for Mouse WD repeat domain-containing protein 83
    Monoclonal Antibody for Mouse WD repeat domain-containing protein 83
    Protein for Mouse WD repeat domain-containing protein 83
    Protein for Mouse WD repeat domain-containing protein 83
    Protein for Mouse WD repeat domain-containing protein 83

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists."
      Vomastek T. , Schaeffer H.-J. , Tarcsafalvi A. , Smolkin M.E. , Bissonette E.A. , Weber M.J.
      Proc. Natl. Acad. Sci. U.S.A.101:6981-6986(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH MAP2K1; MAP2K2; LAMTOR3; ARAF; MAPK1 AND MAPK3
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Testis.
      tissue: Urinary bladder.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      strain: C57BL/6J.
      strain: Czech II.
      strain: FVB/N.
      tissue: Mammary gland.
      tissue: Mammary tumor.
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