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Index > Protein center > Wee2(Gene name) > Mouse
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  • Wee2 (Gene name),
  • Wee1-like protein kinase 2 (Protein name ),  WEE2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Wee2(Wee1b);
    Protein name:
    Wee1-like protein kinase 2;
    Alternative:
    Wee1B kinase(mWee1B);Wee1-like protein kinase 1B;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
    Subcellular Location:
    Cytoplasm Nucleus Localizes mainly in the nucleus. Exported from the nucleus to the cytoplasm before germinal vesicle breakdown (GVBD), allowing meiosis resumption.
    Protein Attributes:
    Sequence length:
    555
    Sequence:
    50:
    MADTETDQGL | NKKLSFSFCE | EDTESEGQMT | AQDIGGAQSQ | KPGREESEEL | 
    100:
    EGPVPPTRDE | LHTSLSRDKE | SPGPDLWKSV | SGPPKCPETP | VLHSKSKLPV | 
    150:
    PTNFSTPKNS | LGQPEISLLE | KLSSRSSRHM | RLTPASLMDE | KTSLSLVNIN | 
    200:
    PFTPETYRKL | LLQSKGKRKT | RDYLEETGEE | ESKSVQWLPA | KRSILQETNM | 
    250:
    ASRYEKEFFE | IEKIGVGEFG | TVYKCIKRLD | GCIYAIKRSA | KSFSGLSNEL | 
    300:
    DLHEVYAHAV | LGHHPHVVRY | YSSWIEDDHV | VIQNEYCNGG | SLQAAISENT | 
    350:
    ASNNHFQEPK | LKDILLQISL | GLKYIHNSGM | VHLDIKPSNI | FICHKMQCDS | 
    400:
    PVGPEEAESE | ADWFLNASVM | YKIGDLGHAT | SISKPKVEEG | DTRFLANEIL | 
    450:
    QENYQHLPKA | DIFALGLTIA | VAAGAESLPI | NGDMWHHIRK | GNFPEISQEL | 
    500:
    SDDFYGLLKN | MIHPAPKERP | SAAALARSRI | LWPFLEKTDE | LQKQLNLEKS | 
    550:
    KTATLKRELK | KARHIQTPQR | EVHHCYYQIC | KGSRHLLVGG | RRKAPSSFTR | 
    555:
    GTSSV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Wee1-like protein kinase 2
    ELISA Kit for Mouse Wee1-like protein kinase 2
    ELISA Kit for Mouse Wee1-like protein kinase 2
    ELISA Kit for Mouse Wee1-like protein kinase 2
    ELISA Kit for Mouse Wee1-like protein kinase 2
    CLIA Kit for Mouse Wee1-like protein kinase 2
    CLIA Kit for Mouse Wee1-like protein kinase 2
    CLIA Kit for Mouse Wee1-like protein kinase 2
    CLIA Kit for Mouse Wee1-like protein kinase 2
    CLIA Kit for Mouse Wee1-like protein kinase 2
    Polyclonal Antibody for Mouse Wee1-like protein kinase 2
    Polyclonal Antibody for Mouse Wee1-like protein kinase 2
    Polyclonal Antibody for Mouse Wee1-like protein kinase 2
    Polyclonal Antibody for Mouse Wee1-like protein kinase 2
    Polyclonal Antibody for Mouse Wee1-like protein kinase 2
    Monoclonal Antibody for Mouse Wee1-like protein kinase 2
    Monoclonal Antibody for Mouse Wee1-like protein kinase 2
    Monoclonal Antibody for Mouse Wee1-like protein kinase 2
    Monoclonal Antibody for Mouse Wee1-like protein kinase 2
    Monoclonal Antibody for Mouse Wee1-like protein kinase 2
    Protein for Mouse Wee1-like protein kinase 2
    Protein for Mouse Wee1-like protein kinase 2
    Protein for Mouse Wee1-like protein kinase 2
    Protein for Mouse Wee1-like protein kinase 2
    Protein for Mouse Wee1-like protein kinase 2

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    Linearity
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    References
    1. 1.
      "Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse."
      Han S.J. , Chen R. , Paronetto M.P. , Conti M.
      Curr. Biol.15:1670-1676(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION AT SER-15;MUTAGENESIS OF SER-15
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Egg.
      tissue: Ovary.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Egg.
    4. 4.
      "Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases."
      Nakanishi M. , Ando H. , Watanabe N. , Kitamura K. , Ito K. , Okayama H. , Miyamoto T. , Agui T. , Sasaki M.
      Genes Cells5:839-847(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    5. 5.
      "Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption."
      Oh J.S. , Han S.J. , Conti M.
      J. Cell Biol.188:199-207(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF 167-LYS--LYS-169; LYS-237; LEU-311; LEU-316; LEU-320 AND LEU-322
    6. 6.
      "Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes."
      Oh J.S. , Susor A. , Conti M.
      Science332:462-465(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;PHOSPHORYLATION AT SER-15;MUTAGENESIS OF SER-15 AND LYS-237
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