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Index > Protein center > WISP1(Gene name) > Human
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  • WISP1 (Gene name),
  • WNT1-inducible-signaling pathway protein 1 (Protein name ),  WISP1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    WISP1(CCN4);
    Protein name:
    WNT1-inducible-signaling pathway protein 1(WISP-1);
    Alternative:
    Wnt-1-induced secreted protein;CCN family member 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    367
    Sequence:
    50:
    MRWFLPWTLA | AVTAAAASTV | LATALSPAPT | TMDFTPAPLE | DTSSRPQFCK | 
    100:
    WPCECPPSPP | RCPLGVSLIT | DGCECCKMCA | QQLGDNCTEA | AICDPHRGLY | 
    150:
    CDYSGDRPRY | AIGVCAQVVG | VGCVLDGVRY | NNGQSFQPNC | KYNCTCIDGA | 
    200:
    VGCTPLCLRV | RPPRLWCPHP | RRVSIPGHCC | EQWVCEDDAK | RPRKTAPRDT | 
    250:
    GAFDAVGEVE | AWHRNCIAYT | SPWSPCSTSC | GLGVSTRISN | VNAQCWPEQE | 
    300:
    SRLCNLRPCD | VDIHTLIKAG | KKCLAVYQPE | ASMNFTLAGC | ISTRSYQPKY | 
    350:
    CGVCMDNRCC | IPYKSKTIDV | SFQCPDGLGF | SRQVLWINAC | FCNLSCRNPN | 
    367:
    DIFADLESYP | DFSEIAN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    String:
    MIM:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human WISP-1
    Cat.:
    E1116m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human WISP-1
    Cat.:
    E1116h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human WISP-1
    Cat.:
    E1116r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human WISP-1
    Cat.:
    U1116h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human WISP-1
    Cat.:
    U1116m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human WISP-1
    Cat.:
    U1116r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human WISP-1
    Cat.:
    P1116Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human WISP-1
    Cat.:
    P1116Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human WISP-1
    Cat.:
    P1116Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human WISP-1
    Monoclonal Antibody for Human WISP-1
    Monoclonal Antibody for Human WISP-1
    Protein for Human WISP-1
    Protein for Human WISP-1
    Protein for Human WISP-1

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    References
    1. 1.
      "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
      Pennica D. , Swanson T.A. , Welsh J.W. , Roy M.A. , Lawrence D.A. , Lee J. , Brush J. , Taneyhill L.A. , Deuel B. , Lew M. , Watanabe C. , Cohen R.L. , Melham M.F. , Finley G.G. , Quirke P. , Goddard A.D. , Hillan K.J. , Gurney A.L. , more...
      Proc. Natl. Acad. Sci. U.S.A.95:14717-14722(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal kidney.
      tissue: Lung.
    2. 2.
      "A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma."
      Tanaka S. , Sugimachi K. , Saeki H. , Kinoshita J. , Ohga T. , Shimada M. , Maehara Y. , Sugimachi K.
      Oncogene20:5525-5532(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Gastric carcinoma.
    3. 3.
      "Multiple alternatively spliced variants of WISP1 are overexpressed in pancreatic cancer."
      Li Z. , Chiao P.J. , Evans D.B.
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
      tissue: Synovium.
      tissue: Uterus.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    7. 8.
      "WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene."
      Xu L. , Corcoran R.B. , Welsh J.W. , Pennica D. , Levine A.J.
      Genes Dev.14:585-595(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN WNT1 SIGNALING
    8. 9.
      "WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase."
      Su F. , Overholtzer M. , Besser D. , Levine A.J.
      Genes Dev.16:46-57(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TP53-MEDIATED APOPTOSIS
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DECORIN AND BIGLYCAN
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