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Index > Protein center > Wnk1(Gene name) > Mouse
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  • Wnk1 (Gene name),
  • Serine/threonine-protein kinase WNK1 (Protein name ),  WNK1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Wnk1(Hsn2;Prkwnk1);
    Protein name:
    Serine/threonine-protein kinase WNK1;
    Alternative:
    Protein kinase with no lysine 1;Protein kinase lysine-deficient 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with SYT2 (By similarity). Interacts with WNK3 and WNK4.
    Function:
    Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    2377
    Sequence:
    50:
    MSDGAAEKQS | GTPGFLTPPA | PVPKNGSSSD | SSVGEKLGAT | VADSGVGRTE | 
    100:
    EYRRRRHTMD | KDSRGAAATT | TPTEHRFFRR | SVICDSNATA | LELPGLPLSI | 
    150:
    PQPSVPAVVP | QSAPPEPHRE | ETLTATVASQ | VSQQPSAAAS | PGEQAVVGSA | 
    200:
    TTTVPSSTSK | DRPVSQPSLV | GSKEEPPPSR | SGSGSGGASA | KEAQEDRSQQ | 
    250:
    QDDIEELETK | AVGMSNDGRF | LKFDIEIGRG | SFKTVYKGLD | TETTVEVAWC | 
    300:
    ELQDRKLTKS | ERQRFKEEAE | MLKGLQHPNI | VRFYDSWEST | VKGKKCIVLV | 
    350:
    TELMTSGTLK | TYLKRFKVMK | IKVLRSWCRQ | ILKGLQFLHT | RTPPIIHRDL | 
    400:
    KCDNIFITGP | TGSVKIGDLG | LATLKRASFA | KSVIGTPEFM | APEMYEEKYD | 
    450:
    ESVDVYAFGM | CMLEMATSEY | PYSECQNAAQ | IYRRVTSGVK | PASFDKVAIP | 
    500:
    EVKEIIEGCI | RQNKDERYSI | KDLLNHAFFQ | EETGVRVELA | EEDDGEKIAI | 
    550:
    KLWLRIEDIK | KLKGKYKDNE | AIEFSFDLER | DVPEDVAQEM | VESGYVCEGD | 
    600:
    HKTMAKAIKD | RVSLIKRKRE | QRQLVREEQE | KRKQEESSFK | QQNEQQASVS | 
    650:
    QAGIQQLSAA | STGIPTAPAT | SASVSTQVEP | EEPEADQHQQ | LQYQQPSISV | 
    700:
    LSDGTIDSGQ | GSSVFTESRV | SSQQTVSYGS | QHEQAHSTGT | APGHTVSSIQ | 
    750:
    AQSQPHGVYP | PSSMAQGQNQ | GQPSSSLAGV | LSSQPIQHPQ | QQGIQPTVPS | 
    800:
    QQAVQYSLPQ | AASSSEGTTA | QPVSQPQVSA | GTQLPVSQTV | ATVQGEPHIP | 
    850:
    VSTQPSVVPV | HSGAHFLPMG | QPIPTSLLPQ | YPVSQIPIST | PHVSTAQTGF | 
    900:
    SSVPITMAAG | INQPLLTLAS | SATASSIPGG | SPVVPNQLPT | LLQPVNQLQS | 
    950:
    QVHPQLLQPT | TVQSIGIPAN | LGQAAEGPLP | SGDVLYQGFP | SRLPPQYPGD | 
    1000:
    SNIAPSSNVA | SVCIHSTVLA | PPSMPTEALA | TQGYFPTVVQ | PYVESTPLVP | 
    1050:
    MGSVGGQVQV | SQPAVSLTQQ | PPTTSSQQAV | LESTQGVSQA | APPEQTPITQ | 
    1100:
    SQPTQPVPLV | TSADSAHSDV | ASGMSDGNEN | APSSSGRHEG | RTTKRHYRKS | 
    1150:
    VRSRSRHEKT | SRPKLRILNV | SNKGDRVVEC | QLETHNRKMV | TFKFDLDGDN | 
    1200:
    PEEIATIMVN | NDFILAIERE | SFVAQVREII | EKADEMLSED | VSVEPEGDQG | 
    1250:
    LESLQGKDDY | GFPGSQKLEG | EFKQPIAVSS | MPQQIGVPTS | SLTQVVHSAG | 
    1300:
    RRFIVSPVPE | SRLRESKVFT | SDISDPVVAS | TSQAPGMNLS | HSASSLSLQQ | 
    1350:
    AFSELKHGQM | TEGPNTAPPN | FNHMAGPTFS | PFLASIAGVQ | TVAASTPSVS | 
    1400:
    VPITSSPLND | ISTSVMQSET | ALPTEKGIVG | VTTTSTGVVA | SGGLTTMSVS | 
    1450:
    ESPTSSSAVS | SSTVPAVVTV | STPSQPVQAS | TSGSIASSTG | SFPPGTFSTT | 
    1500:
    TATTMGSVVA | PDAKPPTVLL | QQVASNTAGV | AIVTSVSTTT | PFPGMASQPS | 
    1550:
    LPLSSSTSAP | TLAETMVVSA | HSLDKASHSS | TAGLGLSFCA | PSSSSSSGTA | 
    1600:
    VSTSVSQPGM | VHPLVISSAV | VSTPGLPQPV | VPTSTPLLPQ | VPNIPPLVQP | 
    1650:
    VVNVPAVQQT | LIHSQPQPAL | LPNQPHTHCP | EMDADTQSKA | PGIDDIKTLE | 
    1700:
    EKLRSLFSEH | SSSGTQHASV | SLETPLVVET | TVTPGITTTA | VAPSKLMTST | 
    1750:
    TSTCLPPTSL | PLGAAGMPVM | PVGTPGQVST | PGTHASAPVG | TATGVKPGTT | 
    1800:
    PPKPTKTVVP | PVGTELSAGT | VPCEQLPPFP | GPSLIQSQQP | LEDLDAQLRR | 
    1850:
    TLSPETITVA | PAVGPLSTMS | STTVTEAGTR | LQKDGTEGHV | TATSSGAGVV | 
    1900:
    KMGRFQVSVT | MDDAQKERKN | RSEDTKSVHF | ESSTSESSVL | SSSSPESTLV | 
    1950:
    KPEPNGISIS | GISLDVPDST | HKAPTPEAKS | DAGQPTKVGR | FQVTTTANKV | 
    2000:
    GRFSVSRTED | KVTELKKEGP | VTSPPFRDSE | QTVIPAVIPK | KEKPELAEPS | 
    2050:
    HLNGPSSDLE | AAFLSRGTED | GSGSPHSPPH | LCSKSLPVQN | LSQSLSNSFN | 
    2100:
    SSYMSSDNES | DIEDEDLRLE | LRRLREKHLK | EIQDLQSRQK | HEIESLYTKL | 
    2150:
    GKVPPAVIIP | PAAPLSGRRR | RPTKSKGSKS | SRSSSLGNKS | PQLSGNLSGQ | 
    2200:
    SGTSVLHPQQ | TLHPAGNTPE | TGHNQLLQPL | KPSPSSDNLY | SAFTSDGAIS | 
    2250:
    VPSLSAPGQG | TSSTNTVGGT | VSSQAAQAQP | PAMTSSRKGT | FTDDLHKLVD | 
    2300:
    NWARDAMNLS | GRRGSKGHMN | YEGPGMARKF | SAPGQLCVPM | TSNLGGSTPI | 
    2350:
    SAASATSLGH | FTKSMCPPQQ | YGFPPAPFGT | QWSGTGGPAP | QPLGQFQPVG | 
    2377:
    TASLQNFNIS | NLQKSISNPP | GSNLRTT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Serine/threonine-protein kinase WNK1
    ELISA Kit for Mouse Serine/threonine-protein kinase WNK1
    ELISA Kit for Mouse Serine/threonine-protein kinase WNK1
    ELISA Kit for Mouse Serine/threonine-protein kinase WNK1
    CLIA Kit for Mouse Serine/threonine-protein kinase WNK1
    CLIA Kit for Mouse Serine/threonine-protein kinase WNK1
    CLIA Kit for Mouse Serine/threonine-protein kinase WNK1
    CLIA Kit for Mouse Serine/threonine-protein kinase WNK1
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase WNK1
    Protein for Mouse Serine/threonine-protein kinase WNK1
    Protein for Mouse Serine/threonine-protein kinase WNK1
    Protein for Mouse Serine/threonine-protein kinase WNK1
    Protein for Mouse Serine/threonine-protein kinase WNK1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain."
      O'Reilly M. , Marshall E. , Speirs H.J. , Brown R.W.
      J. Am. Soc. Nephrol.14:2447-2456(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;ALTERNATIVE SPLICING
      strain: C57BL/6.
    2. 2.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
      DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
      tissue: Embryonic tail.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5);PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2/3)
      strain: C57BL/6.
      tissue: Embryo.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-578
      strain: C57BL/6J.
      tissue: Embryo.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 7.
      "WNK kinases regulate thiazide-sensitive Na-Cl cotransport."
      Yang C.-L. , Angell J. , Mitchell R. , Ellison D.H.
      J. Clin. Invest.111:1039-1045(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF THE HSN2 EXON
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2027;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    10. 10.
      "Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II."
      Shekarabi M. , Girard N. , Riviere J.B. , Dion P. , Houle M. , Toulouse A. , Lafreniere R.G. , Vercauteren F. , Hince P. , Laganiere J. , Rochefort D. , Faivre L. , Samuels M. , Rouleau G.A.
      J. Clin. Invest.118:2496-2505(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 3);TISSUE SPECIFICITY
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