Wnk4 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comWnk4 ELISA Kit for Rat(Rattus norvegicus)

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Wnk4 (Gene name),

Serine/threonine-protein kinase WNK4 (Protein name ), WNK4_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Wnk4(Prkwnk4);

Protein name:

Serine/threonine-protein kinase WNK4;

Alternative:

Protein kinase with no lysine 4;Protein kinase lysine-deficient 4;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with the C-terminal region of KCNJ1 (By similarity). Interacts with WNK1 and WNK3.

Function:

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L.

Subcellular Location:

Cell junction tight junction Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex.

Protein Attributes:

Sequence length:

1222

Sequence:

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1222:

STGSQEQRAS | KGVTFAGDVG | RM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.228251

KEGG:

rno:287715

String:

Q7TPK6

Pfam:

PF12202

SMR:

Q7TPK6

Uniprot:

Q7TPK6

FOR

ELISA Kit for Rat Serine/threonine-protein kinase WNK4

CLIA Kit for Rat Serine/threonine-protein kinase WNK4

Polyclonal Antibody for Rat Serine/threonine-protein kinase WNK4

Monoclonal Antibody for Rat Serine/threonine-protein kinase WNK4

Protein for Rat Serine/threonine-protein kinase WNK4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10."
Monti J. , Zimdahl H. , Schulz H. , Plehm R. , Ganten D. , Hubner N.
Hypertension41:938-942(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Wistar Kyoto.
tissue: Kidney.
2.

"WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion."
Kahle K.T. , Wilson F.H. , Leng Q. , Lalioti M.D. , O'Connell A.D. , Dong K. , Rapson A.K. , MacGregor G.G. , Giebisch G. , Hebert S.C. , Lifton R.P.
Nat. Genet.35:372-376(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Wistar Kyoto.
tissue: Kidney.

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