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Index > Protein center > WNT1(Gene name) > Human
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  • WNT1 (Gene name),
  • Proto-oncogene Wnt-1 (Protein name ),  WNT1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    WNT1(INT1);
    Protein name:
    Proto-oncogene Wnt-1;
    Alternative:
    Proto-oncogene Int-1 homolog;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS.
    Function:
    Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    370
    Sequence:
    50:
    MGLWALLPGW | VSATLLLALA | ALPAALAANS | SGRWWGIVNV | ASSTNLLTDS | 
    100:
    KSLQLVLEPS | LQLLSRKQRR | LIRQNPGILH | SVSGGLQSAV | RECKWQFRNR | 
    150:
    RWNCPTAPGP | HLFGKIVNRG | CRETAFIFAI | TSAGVTHSVA | RSCSEGSIES | 
    200:
    CTCDYRRRGP | GGPDWHWGGC | SDNIDFGRLF | GREFVDSGEK | GRDLRFLMNL | 
    250:
    HNNEAGRTTV | FSEMRQECKC | HGMSGSCTVR | TCWMRLPTLR | AVGDVLRDRF | 
    300:
    DGASRVLYGN | RGSNRASRAE | LLRLEPEDPA | HKPPSPHDLV | YFEKSPNFCT | 
    350:
    YSGRLGTAGT | AGRACNSSSP | ALDGCELLCC | GRGHRTRTQR | VTERCNCTFH | 
    370:
    WCCHVSCRNC | THTRVLHECL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    SMR:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Proto-oncogene Wnt-1
    Cat.:
    E1414h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Proto-oncogene Wnt-1
    Cat.:
    E1414c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Proto-oncogene Wnt-1
    Cat.:
    E1414m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Proto-oncogene Wnt-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Proto-oncogene Wnt-1
    Cat.:
    U1414h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Proto-oncogene Wnt-1
    Cat.:
    U1414m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Proto-oncogene Wnt-1
    Cat.:
    P1414Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Proto-oncogene Wnt-1
    Polyclonal Antibody for Human Proto-oncogene Wnt-1
    Cat.:
    P1414Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Proto-oncogene Wnt-1
    Monoclonal Antibody for Human Proto-oncogene Wnt-1
    Monoclonal Antibody for Human Proto-oncogene Wnt-1
    Protein for Human Proto-oncogene Wnt-1
    Protein for Human Proto-oncogene Wnt-1
    Protein for Human Proto-oncogene Wnt-1

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    References
    1. 1.
      "The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences."
      van Ooyen A. , Kwee V. , Nusse R.
      EMBO J.4:2905-2909(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    5. 5.
      "Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling."
      Doubravska L. , Krausova M. , Gradl D. , Vojtechova M. , Tumova L. , Lukas J. , Valenta T. , Pospichalova V. , Fafilek B. , Plachy J. , Sebesta O. , Korinek V.
      Cell. Signal.23:837-848(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY CYSTEINE PALMITOYLATION;PALMITOYLATION AT SER-224
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN BMND16;VARIANTS OI15 CYS-177 AND CYS-298;VARIANT OSTEOP TRP-235;CHARACTERIZATION OF VARIANT OI15 CYS-177;CHARACTERIZATION OF VARIANT OSTEOP TRP-235
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN OI15;VARIANT OSTEOP GLY-218;CHARACTERIZATION OF VARIANT OSTEOP GLY-218
    8. 8.
      "WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta."
      Pyott S.M. , Tran T.T. , Leistritz D.F. , Pepin M.G. , Mendelsohn N.J. , Temme R.T. , Fernandez B.A. , Elsayed S.M. , Elsobky E. , Verma I. , Nair S. , Turner E.H. , Smith J.D. , Jarvik G.P. , Byers P.H.
      Am. J. Hum. Genet.92:590-597(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OI15 CYS-298
    9. 9.
      "Mutations in WNT1 are a cause of osteogenesis imperfecta."
      Fahiminiya S. , Majewski J. , Mort J. , Moffatt P. , Glorieux F.H. , Rauch F.
      J. Med. Genet.50:345-348(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OI15 PHE-143 AND PHE-355
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