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Index > Protein center > WNT5A(Gene name) > Human
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  • WNT5A (Gene name),
  • Protein Wnt-5a (Protein name ),  WNT5A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    WNT5A;
    Protein name:
    Protein Wnt-5a;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PORCN (By similarity). Interacts with WLS.
    Function:
    Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    380
    Sequence:
    50:
    MKKSIGILSP | GVALGMAGSA | MSSKFFLVAL | AIFFSFAQVV | IEANSWWSLG | 
    100:
    MNNPVQMSEV | YIIGAQPLCS | QLAGLSQGQK | KLCHLYQDHM | QYIGEGAKTG | 
    150:
    IKECQYQFRH | RRWNCSTVDN | TSVFGRVMQI | GSRETAFTYA | VSAAGVVNAM | 
    200:
    SRACREGELS | TCGCSRAARP | KDLPRDWLWG | GCGDNIDYGY | RFAKEFVDAR | 
    250:
    ERERIHAKGS | YESARILMNL | HNNEAGRRTV | YNLADVACKC | HGVSGSCSLK | 
    300:
    TCWLQLADFR | KVGDALKEKY | DSAAAMRLNS | RGKLVQVNSR | FNSPTTQDLV | 
    350:
    YIDPSPDYCV | RNESTGSLGT | QGRLCNKTSE | GMDGCELMCC | GRGYDQFKTV | 
    380:
    QTERCHCKFH | WCCYVKCKKC | TEIVDQFVCK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    MIM:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein Wnt-5a
    Cat.:
    E1038h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Protein Wnt-5a
    Cat.:
    E1038m
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    MSDS:
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    96T
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    ELISA Kit for Human Protein Wnt-5a
    Cat.:
    E1038r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Protein Wnt-5a
    MSDS:
    Please sign in first.
    CLIA Kit for Human Protein Wnt-5a
    Cat.:
    U1038r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein Wnt-5a
    Cat.:
    U1038m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Protein Wnt-5a
    MSDS:
    Please sign in first.
    CLIA Kit for Human Protein Wnt-5a
    Cat.:
    U1038h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Protein Wnt-5a
    Cat.:
    P1038Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Wnt-5a
    Polyclonal Antibody for Human Protein Wnt-5a
    Cat.:
    P1038Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Wnt-5a
    Cat.:
    P1038Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Protein Wnt-5a
    Monoclonal Antibody for Human Protein Wnt-5a
    Monoclonal Antibody for Human Protein Wnt-5a
    Monoclonal Antibody for Human Protein Wnt-5a
    Protein for Human Protein Wnt-5a
    Protein for Human Protein Wnt-5a
    Protein for Human Protein Wnt-5a
    Protein for Human Protein Wnt-5a

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    Linearity
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    References
    1. 1.
      "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21."
      Clark C.C. , Cohen I.R. , Eichstetter I. , Cannizarro L.A. , McPherson J.D. , Wasmuth J.J. , Iozzo R.V.
      Genomics18:249-260(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Mesangial cell.
      tissue: Tongue.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    5. 5.
      "Wnt-5a has tumor suppressor activity in thyroid carcinoma."
      Kremenevskaja N. , von Wasielewski R. , Rao A.S. , Schoefl C. , Andersson T. , Brabant G.
      Oncogene24:2144-2154(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    6. 6.
      "The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition."
      Dissanayake S.K. , Wade M. , Johnson C.E. , O'Connell M.P. , Leotlela P.D. , French A.D. , Shah K.V. , Hewitt K.J. , Rosenthal D.T. , Indig F.E. , Jiang Y. , Nickoloff B.J. , Taub D.D. , Trent J.M. , Moon R.T. , Bittner M. , Weeraratna A.T.
      J. Biol. Chem.282:17259-17271(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DRS SER-83 AND ARG-182;CHARACTERIZATION OF VARIANTS DRS SER-83 AND ARG-182
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