Protein name:
ATPase WRNIP1 ;
Alternative:
Werner helicase-interacting protein 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homooligomer; most likely an octamer. Interacts with POLD1, POLD2 an POLD4. Interacts (via UBZ-type zinc finger) with polyubiquitin (By similarity). Interacts with the N-terminal domain of WRN.
Function:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
Subcellular Location:
Nucleus
Colocalizes with WRN in granular structures in the nucleus.
Protein Attributes:
50:
MEVSGPEDDP | FLSQLHQVQC | PVCQQMMPAA | HINSHLDRCL | LLHPAGHAEP |
100:
AAGSHRAGER | AKGPSPPGAK | RRRLSESSAL | KQPATPTAAE | SSEGEGEEGD |
150:
DGGETESRES | YDAPPTPSGA | RLIPDFPVAR | SSSPARKGMG | KRPAAAAAAG |
200:
SASPRSWDEA | EAQEEEEAGV | DGDGDADVDG | EDDPGHWDAD | AADASFGVSA |
250:
GRAHPRALAA | EEIRQMLEGK | PLADKMRPDT | LQDYIGQSRA | VGQETLLRSL |
300:
LEANEIPSLI | LWGPPGCGKT | TLAHIIANNS | KKHSIRFVTL | SATNAKTNDV |
350:
RDVIKQAQNE | KSFFKRKTIL | FIDEIHRFNK | SQQDTFLPHV | ECGTITLIGA |
400:
TTENPSFQVN | AALLSRCRVI | VLEKLPVEAM | VTILMRAINS | LGIHVLDSSR |
450:
PTDPLSHSSN | CSSEPSVFIE | DKAVDTLAYL | SDGDARTGLN | GLQLAVLARL |
500:
SSRKVFCKKS | GQTYSPSRVL | ITENDVKEGL | QRSHILYDRA | GEEHYNCISA |
550:
LHKAMRGSDQ | NASLYWLARM | LEGGEDPLYV | ARRLVRFASE | DIGLADPSAL |
600:
AQAVAAYQGC | HFIGMPECEV | LLAQCVVYFA | RAPKSIEVYS | AYNNVKACLR |
650:
SHQGPLPPVP | LHLRNAPTRL | MKDLGYGKGY | KYNPMYSEPV | DQDYLPEELR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse ATPase WRNIP1
ELISA Kit for Mouse ATPase WRNIP1
ELISA Kit for Mouse ATPase WRNIP1
CLIA Kit for Mouse ATPase WRNIP1
CLIA Kit for Mouse ATPase WRNIP1
CLIA Kit for Mouse ATPase WRNIP1
Polyclonal Antibody for Mouse ATPase WRNIP1
Polyclonal Antibody for Mouse ATPase WRNIP1
Polyclonal Antibody for Mouse ATPase WRNIP1
Monoclonal Antibody for Mouse ATPase WRNIP1
Monoclonal Antibody for Mouse ATPase WRNIP1
Monoclonal Antibody for Mouse ATPase WRNIP1
Protein for Mouse ATPase WRNIP1
Protein for Mouse ATPase WRNIP1
Protein for Mouse ATPase WRNIP1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A novel protein interacts with the Werner's syndrome gene product physically and functionally."
Kawabe Y.
,
Branzei D.
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Hayashi T.
,
Suzuki H.
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Masuko T.
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Onoda F.
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Heo S.-J.
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Enomoto T.
J. Biol. Chem.276:20364-20369(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH WRN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
C57BL/6 .
tissue :
Testis .
2.
"The transcriptional landscape of the mammalian genome."
Carninci P.
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Kasukawa T.
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Katayama S.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
strain :
NOD .
tissue :
Cerebellum .
tissue :
Liver .
tissue :
Placenta .
tissue :
Thymus .
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
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Goodstadt L.
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Bult C.J.
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,
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,
Forrest D.
,
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Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
Czech II .
strain :
FVB/N-3 .
tissue :
Mammary gland .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 182-660 (ISOFORM 1)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .