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Index > Protein center > Ybx2(Gene name) > Mouse
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  • Ybx2 (Gene name),
  • Y-box-binding protein 2 (Protein name ),  YBOX2_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Ybx2(Msy2);
    Protein name:
    Y-box-binding protein 2;
    Alternative:
    Germ cell-specific Y-box-binding protein;FRGY2 homolog;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Found in a mRNP complex with PABPC1 and CSDA.
    Function:
    Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    360
    Sequence:
    50:
    MSEAEASVVA | TAAPAATVPA | TAAGVVAVVV | PVPAGEPQKA | GGGAGGGGGA | 
    100:
    ASGPAAGTPL | HAPGPRTPGN | QATAASGTPA | PPARSQADKP | VLAIQVLGTV | 
    150:
    KWFNVRNGYG | FINRNDTKED | VFVHQTAIKR | NNPRKFLRSV | GDGETVEFDV | 
    200:
    VEGEKGARAA | NVTGPGGVPV | KGSRYAPNRR | RFRRFIPRPR | PAAPPPMVAE | 
    250:
    APSGGTEPGS | EGERAEDSGQ | RPRRRRPPPF | FYRRRFVRGP | RPPNQQQPIE | 
    300:
    GSDGVEPKET | APLEGDQQQG | DERVPPPRFR | PRYRRPFRPR | PPQQPTTEGG | 
    350:
    DGETKPSQGP | TDGSRPEPQR | PRNRPYFQRR | RQQPPGPRQP | IAAETSAPIN | 
    360:
    SGDPPTTILE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Y-box-binding protein 2
    ELISA Kit for Mouse Y-box-binding protein 2
    CLIA Kit for Mouse Y-box-binding protein 2
    CLIA Kit for Mouse Y-box-binding protein 2
    Polyclonal Antibody for Mouse Y-box-binding protein 2
    Polyclonal Antibody for Mouse Y-box-binding protein 2
    Monoclonal Antibody for Mouse Y-box-binding protein 2
    Monoclonal Antibody for Mouse Y-box-binding protein 2
    Protein for Mouse Y-box-binding protein 2
    Protein for Mouse Y-box-binding protein 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Mammalian male and female germ cells express a germ cell-specific Y-box protein, MSY2."
      Gu W. , Tekur S. , Reinbold R. , Eppig J.J. , Choi Y.-C. , Zheng J.Z. , Murray M.T. , Hecht N.B.
      Biol. Reprod.59:1266-1274(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
      strain: CD-1.
      tissue: Testis.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs."
      Herbert T.P. , Hecht N.B.
      Nucleic Acids Res.27:1747-1753(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MRNA TRANSLATION;PHOSPHORYLATION;RNA-BINDING;IDENTIFICATION IN A MRNP COMPLEX WITH PABPC1
    4. 4.
      "A sequence-specific RNA binding complex expressed in murine germ cells contains MSY2 and MSY4."
      Davies H.G. , Giorgini F. , Fajardo M.A. , Braun R.E.
      Dev. Biol.221:87-100(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A MRNP COMPLEX WITH YBX3
      tissue: Testis.
    5. 5.
      "Expression of MSY2 in mouse oocytes and preimplantation embryos."
      Yu J. , Hecht N.B. , Schultz R.M.
      Biol. Reprod.65:1260-1270(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    6. 6.
      "MSY2 and MSY4 bind a conserved sequence in the 3' untranslated region of protamine 1 mRNA in vitro and in vivo."
      Giorgini F. , Davies H.G. , Braun R.E.
      Mol. Cell. Biol.21:7010-7019(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA-BINDING
    7. 7.
      "RNA-binding properties and translation repression in vitro by germ cell-specific MSY2 protein."
      Yu J. , Hecht N.B. , Schultz R.M.
      Biol. Reprod.67:1093-1098(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MRNA TRANSLATION;RNA-BINDING
    8. 8.
      "Requirement for RNA-binding activity of MSY2 for cytoplasmic localization and retention in mouse oocytes."
      Yu J. , Hecht N.B. , Schultz R.M.
      Dev. Biol.255:249-262(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MATERNAL MRNA CYTOPLASMIC RETENTION;RNA-BINDING;MUTAGENESIS OF TYR-109 AND PHE-111
    9. 9.
      "Transgenic RNAi-mediated reduction of MSY2 in mouse oocytes results in reduced fertility."
      Yu J. , Deng M. , Medvedev S. , Yang J. , Hecht N.B. , Schultz R.M.
      Dev. Biol.268:195-206(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MRNA STABILITY
    10. 10.
      "The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells."
      Yang J. , Medvedev S. , Reddi P.P. , Schultz R.M. , Hecht N.B.
      Proc. Natl. Acad. Sci. U.S.A.102:1513-1518(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOPLASMIC MRNA STORAGE;RNA-BINDING;DNA-BINDING
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