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Association of interleukin-1A insertion/deletion gene polymorphism and possible high risk factors with non-alcoholic fatty liver disease in Egyptian
Update time:2017-07-09 23:07:38   【 Font: Large  Medium Small

ABSTRACT

Context: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression.

Objective: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations.

Methods: The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured.

Results: The major D allele was significantly associated with NAFLD patients (p ¼ .002). DD genotype showed a significant increase in BMI and decrease in HDL-C. Also serum IL-1A was significantly correlated with the DD genotype. Serum IL-1A showed a significant positive correlation with BMI, triglycerides, total cholesterol, LDL-C, VLDL-C and FBG, and a significant negative correlation with HDL-C.

Conclusions: Major D allele of IL-1A (I/D) gene polymorphism is associated with NAFLD in the Egyptian population.                                                                                                                                                                      

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Source:Archives of Physiology and Biochemistry      by Asmaa R. A, Maivel H. G, Noha M. M, et al.
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