Creb1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCreb1 ELISA Kit for Rat(Rattus norvegicus)

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Creb1 (Gene name),

Cyclic AMP-responsive element-binding protein 1 (Protein name ), CREB1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (3)

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Gene name:

Creb1(Creb-1);

Protein name:

Cyclic AMP-responsive element-binding protein 1(CREB-1;cAMP-responsive element-binding protein 1);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with PPRC1. Binds DNA as a dimer. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3 (By similarity). When phosphorylated on Ser-133, binds CREBBP. Interacts with ARRB1. Interacts (phosporylated form) with TOX3. Binds to HIPK2.

Function:

This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

341

Sequence:

50:

100:

150:

200:

250:

300:

341:

RRKKKEYVKC | LENRVAVLEN | QNKTLIEELK | ALKDLYCHKS | D

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00170

STRING:

10116.ENSRNOP00000018326

UniGene:

Rn.90061

SMR:

P15337

String:

P15337

KEGG:

rno:81646

Uniprot:

P15337

FOR

ELISA Kit for Rat CREB-1

Cat.:

E1318h

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96T

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ELISA Kit for Rat CREB-1

Cat.:

E1318r

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96T

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ELISA Kit for Rat CREB-1

Cat.:

E1318m

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96T

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ELISA Kit for Rat CREB-1

Cat.:

E1318b

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Packing:

96T

CLIA Kit for Rat CREB-1

Cat.:

U1318m

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Rat CREB-1

Cat.:

U1318h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

Please sign in first.

CLIA Kit for Rat CREB-1

Cat.:

U1318r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Rat CREB-1

Cat.:

U1318b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat CREB-1

Cat.:

P1318Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat CREB-1

Cat.:

P1318Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat CREB-1

Cat.:

P1318Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat CREB-1

Protein for Rat CREB-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological..."

indal A, Mahesh R, Bhatt S.

From:Psychopharmacology

[2].

"Type 4 phosphodiesterase enzyme inhibitor, rolipram rescues behavioral deficits in olfactory bulbectomy models of depression: Involvement of..."

Jindal A, Mahesh R, Bhatt S.

From:Pharmacology Biochemistry and Behavior

[3].

"Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechan"

A Jindal, R Mahesh, S Bhatt, et al.

From:Neurochemistry International

References

1.

"A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence."
Gonzalez G.A. , Yamamoto K.K. , Fischer W.H. , Karr D. , Menzel P. , Biggs W. III , Vale W.W. , Montminy M.R.
Nature337:749-752(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
2.

"Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells."
Short M.L. , Manohar C.F. , Furtado M.R. , Ghadge G.D. , Wolinsky S.M. , Thimmapaya B. , Jungmann R.A.
Nucleic Acids Res.19:4290-4290(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

"CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases."
Sheng M. , Thompson M.A. , Greenberg M.E.
Science252:1427-1430(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133;PHOSPHORYLATION BY CAMK1 AND CAMK4
4.

"Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity."
Sun P. , Enslen H. , Myung P.S. , Maurer R.A.
Genes Dev.8:2527-2539(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133 AND SER-142;MUTAGENESIS OF SER-133 AND SER-142
5.

"Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV."
Sun P. , Lou L. , Maurer R.A.
J. Biol. Chem.271:3066-3073(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-133;PHOSPHORYLATION BY CAMK1
6.

"Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains."
Radhakrishnan I. , Perez-Alvarado G.C. , Parker D. , Dyson H.J. , Montminy M.R. , Wright P.E.
J. Mol. Biol.287:859-865(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 119-146 IN COMPLEX WITH CREBBP

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