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Index > Protein center > PRG4(Gene name) > Human
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  • PRG4 (Gene name),
  • Proteoglycan 4 (Protein name ),  PRG4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PRG4(MSF;SZP);
    Protein name:
    Proteoglycan 4;
    Alternative:
    Megakaryocyte-stimulating factor;Lubricin;Superficial zone proteoglycan;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1404
    Sequence:
    50:
    MAWKTLPIYL | LLLLSVFVIQ | QVSSQDLSSC | AGRCGEGYSR | DATCNCDYNC | 
    100:
    QHYMECCPDF | KRVCTAELSC | KGRCFESFER | GRECDCDAQC | KKYDKCCPDY | 
    150:
    ESFCAEVHNP | TSPPSSKKAP | PPSGASQTIK | STTKRSPKPP | NKKKTKKVIE | 
    200:
    SEEITEEHSV | SENQESSSSS | SSSSSSSTIR | KIKSSKNSAA | NRELQKKLKV | 
    250:
    KDNKKNRTKK | KPTPKPPVVD | EAGSGLDNGD | FKVTTPDTST | TQHNKVSTSP | 
    300:
    KITTAKPINP | RPSLPPNSDT | SKETSLTVNK | ETTVETKETT | TTNKQTSTDG | 
    350:
    KEKTTSAKET | QSIEKTSAKD | LAPTSKVLAK | PTPKAETTTK | GPALTTPKEP | 
    400:
    TPTTPKEPAS | TTPKEPTPTT | IKSAPTTPKE | PAPTTTKSAP | TTPKEPAPTT | 
    450:
    TKEPAPTTPK | EPAPTTTKEP | APTTTKSAPT | TPKEPAPTTP | KKPAPTTPKE | 
    500:
    PAPTTPKEPT | PTTPKEPAPT | TKEPAPTTPK | EPAPTAPKKP | APTTPKEPAP | 
    550:
    TTPKEPAPTT | TKEPSPTTPK | EPAPTTTKSA | PTTTKEPAPT | TTKSAPTTPK | 
    600:
    EPSPTTTKEP | APTTPKEPAP | TTPKKPAPTT | PKEPAPTTPK | EPAPTTTKKP | 
    650:
    APTTPKEPAP | TTPKETAPTT | PKKLTPTTPE | KLAPTTPEKP | APTTPEELAP | 
    700:
    TTPEEPTPTT | PEEPAPTTPK | AAAPNTPKEP | APTTPKEPAP | TTPKEPAPTT | 
    750:
    PKETAPTTPK | GTAPTTLKEP | APTTPKKPAP | KELAPTTTKE | PTSTTCDKPA | 
    800:
    PTTPKGTAPT | TPKEPAPTTP | KEPAPTTPKG | TAPTTLKEPA | PTTPKKPAPK | 
    850:
    ELAPTTTKGP | TSTTSDKPAP | TTPKETAPTT | PKEPAPTTPK | KPAPTTPETP | 
    900:
    PPTTSEVSTP | TTTKEPTTIH | KSPDESTPEL | SAEPTPKALE | NSPKEPGVPT | 
    950:
    TKTPAATKPE | MTTTAKDKTT | ERDLRTTPET | TTAAPKMTKE | TATTTEKTTE | 
    1000:
    SKITATTTQV | TSTTTQDTTP | FKITTLKTTT | LAPKVTTTKK | TITTTEIMNK | 
    1050:
    PEETAKPKDR | ATNSKATTPK | PQKPTKAPKK | PTSTKKPKTM | PRVRKPKTTP | 
    1100:
    TPRKMTSTMP | ELNPTSRIAE | AMLQTTTRPN | QTPNSKLVEV | NPKSEDAGGA | 
    1150:
    EGETPHMLLR | PHVFMPEVTP | DMDYLPRVPN | QGIIINPMLS | DETNICNGKP | 
    1200:
    VDGLTTLRNG | TLVAFRGHYF | WMLSPFSPPS | PARRITEVWG | IPSPIDTVFT | 
    1250:
    RCNCEGKTFF | FKDSQYWRFT | NDIKDAGYPK | PIFKGFGGLT | GQIVAALSTA | 
    1300:
    KYKNWPESVY | FFKRGGSIQQ | YIYKQEPVQK | CPGRRPALNY | PVYGETTQVR | 
    1350:
    RRRFERAIGP | SQTHTIRIQY | SPARLAYQDK | GVLHNEVKVS | ILWRGLPNVV | 
    1400:
    TSAISLPNIR | KPDGYDYYAF | SKDQYYNIDV | PSRTARAITT | RSGQTLSKVW | 
    1404:
    YNCP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Proteoglycan 4
    Cat.:
    E0959h
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    Packing:
    96T
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    ELISA Kit for Human Proteoglycan 4
    Cat.:
    E0959m
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    Packing:
    96T
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    CLIA Kit for Human Proteoglycan 4
    Cat.:
    U0959m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Proteoglycan 4
    Cat.:
    U0959h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Proteoglycan 4
    Cat.:
    P0959Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Proteoglycan 4
    Cat.:
    P0959Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Proteoglycan 4
    Monoclonal Antibody for Human Proteoglycan 4
    Protein for Human Proteoglycan 4
    Protein for Human Proteoglycan 4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);VARIANTS TRP-180 AND MET-1296
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM E)
      tissue: Synovial cell.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Cloning and production of recombinant PRG4/cartilage superficial zone proteoglycan (SZP) N- and C-terminal domains."
      Jones A.R. , Hughes C.E. , Flannery C.R. , Caterson B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-193 AND 1148-1398
    5. 5.
      "Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism."
      Flannery C.R. , Hughes C.E. , Schumacher B.L. , Tudor D. , Aydelotte M.B. , Kuettner K.E. , Caterson B.
      Biochem. Biophys. Res. Commun.254:535-541(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-90; 158-258 AND 1209-1295;IDENTIFICATION (ISOFORM C)
    6. 6.
      "Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages."
      Liu Y.J. , Lu S.H. , Xu B. , Yang R.C. , Ren Q. , Liu B. , Li B. , Lu M. , Yan F.Y. , Han Z.B. , Han Z.C.
      Blood103:4449-4456(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-376 (ISOFORM F);FUNCTION;SUBCELLULAR LOCATION
      tissue: Fetal liver.
    7. 7.
      "Purification, biochemical characterization, and cloning of a novel megakaryocyte stimulating factor that has megakaryocyte colony stimulating activity."
      Turner K.J. , Fitz L.J. , Temple P. , Jacobs K. , Larson D. , Leary A.C. , Kelleher K. , Giannotti J. , Calvetti J. , Fitzgerald M. , Kriz M.-J. , Ferenz C. , Grobholz J. , Fraser H. , Bean K. , Norton C.R. , Gesner T. , Bhatia S. , more...
      Blood78:279A-279A(1991)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PURIFICATION
      tissue: Urine.
    8. 8.
      "A comparison of vitronectin and megakaryocyte stimulating factor."
      Merberg D.M. , Fitz L.J. , Temple P. , Giannotti J. , Murtha P. , Fitzgerald M. , Scaltreto H. , Kelleher K. , Preissner K. , Kriz R. , Jacobs K. , Turner K.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
    9. 9.
      "A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage."
      Schumacher B.L. , Block J.A. , Schmid T.M. , Aydelotte M.B. , Kuettner K.E.
      Arch. Biochem. Biophys.311:144-152(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INVOLVEMENT IN CACP
    11. 11.
      "Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes."
      Ikegawa S. , Sano M. , Koshizuka Y. , Nakamura Y.
      Cytogenet. Cell Genet.90:291-297(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;IDENTIFICATION (ISOFORMS B; C AND D)
    12. 12.
      "Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts."
      Jay G.D. , Britt D.E. , Cha C.-J.
      J. Rheumatol.27:594-600(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;GLYCOSYLATION
    13. 13.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1159
      tissue: Plasma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    15. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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