TLR4 ELISA Kit for Human(Homo sapiens) | EIAab.comTLR4 ELISA Kit for Human(Homo sapiens)

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TLR4 (Gene name),

Toll-like receptor 4 (Protein name ), TLR4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TLR4;

Protein name:

Toll-like receptor 4;

Alternative:

hToll;

CD:

CD284;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3.

Function:

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

839

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

839:

VLGRHIFWRR | LRKALLDGKS | WNPEGTVGTG | CNWQEATSI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O00206

MIM:

603030

KEGG:

hsa:7099

Pfam:

PF12799

UniGene:

Hs.174312

Pfam:

PF00560

SMR:

O00206

Uniprot:

O00206

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ELISA Kit for Human Toll-like receptor 4

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E0753h

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96T

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ELISA Kit for Human Toll-like receptor 4

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E0753m

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96T

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ELISA Kit for Human Toll-like receptor 4

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E0753r

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96T

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ELISA Kit for Human Toll-like receptor 4

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E0753p

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96T

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ELISA Kit for Human Toll-like receptor 4

Cat.:

E0753b

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96T

CLIA Kit for Human Toll-like receptor 4

Cat.:

U0753b

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96T

CLIA Kit for Human Toll-like receptor 4

Cat.:

U0753h

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MSDS:

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Packing:

96T

CLIA Kit for Human Toll-like receptor 4

Cat.:

U0753p

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MSDS:

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Packing:

96T

CLIA Kit for Human Toll-like receptor 4

Cat.:

U0753r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Toll-like receptor 4

Cat.:

U0753m

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Looking for manual.

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96T

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Polyclonal Antibody for Human Toll-like receptor 4

Cat.:

P0753Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Toll-like receptor 4

Cat.:

P0753Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Toll-like receptor 4

Cat.:

P0753Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Toll-like receptor 4

Cat.:

M0753h

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40ug

Monoclonal Antibody for Human Toll-like receptor 4

Protein for Human Toll-like receptor 4

Cat.:

R0753h

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Packing:

1mg

Purity:

>90%

Protein for Human Toll-like receptor 4

R&D Technical Data

12% SDS-PAGE analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity."
Medzhitov R. , Preston-Hurlburt P. , Janeway C.A. Jr.
Nature388:394-397(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Spleen.
2.

"A family of human receptors structurally related to Drosophila Toll."
Rock F.L. , Hardiman G. , Timans J.C. , Kastelein R.A. , Bazan J.F.
Proc. Natl. Acad. Sci. U.S.A.95:588-593(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Fetal liver.
tissue: Lung.
tissue: Placenta.
3.

"Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)."
Smirnova I. , Poltorak A. , Chan E.K.L. , McBride C. , Beutler B.
Genome Biol.1:RESEARCH002.1-RESEARCH002.10(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-299 AND ILE-399
4.

"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans."
Arbour N.C. , Lorenz E. , Schutte B.C. , Zabner J. , Kline J.N. , Jones M. , Frees K. , Watt J.L. , Schwartz D.A.
Nat. Genet.25:187-191(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-299 AND ILE-399
5.

"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
6.

"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
Georgel P. , Macquin C. , Bahram S.
PLoS ONE4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-299 AND ILE-399
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Hippocampus.
tissue: Kidney.
tissue: Uterus.
8.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Cerebellum.
11.

Liu Z. , Li N. , Wang J. , Xiao W.
Submitted (2007-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-86
12.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-38
13.

"Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."
Xu Y. , Tao X. , Shen B. , Horng T. , Medzhitov R. , Manley J.L. , Tong L.
Nature408:111-115(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-697; ARG-710; ASP-711 AND PRO-714
14.

"MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor."
da Silva Correia J. , Ulevitch R.J.
J. Biol. Chem.277:1845-1854(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-35; ASN-173; ASN-205; ASN-282; ASN-309; ASN-497; ASN-526; ASN-575 AND ASN-624;MUTAGENESIS OF ASN-526 AND ASN-575
15.

"Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B."
Park H.S. , Jung H.Y. , Park E.Y. , Kim J. , Lee W.J. , Bae Y.S.
J. Immunol.173:3589-3593(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOX4
16.

"Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity."
Kim F. , Pham M. , Luttrell I. , Bannerman D.D. , Tupper J. , Thaler J. , Hawn T.R. , Raines E.W. , Schwartz M.W.
Circ. Res.100:1589-1596(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Liu B. , Yang Y. , Qiu Z. , Staron M. , Hong F. , Li Y. , Wu S. , Li Y. , Hao B. , Bona R. , Han D. , Li Z.
Nat. Commun.1:79-79(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HSP90B1
18.

Liu B. , Yang Y. , Qiu Z. , Staron M. , Hong F. , Li Y. , Wu S. , Li Y. , Hao B. , Bona R. , Han D. , Li Z.
Nat. Commun.3:653-653(2012)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
19.

"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."
Stewart C.R. , Stuart L.M. , Wilkinson K. , van Gils J.M. , Deng J. , Halle A. , Rayner K.J. , Boyer L. , Zhong R. , Frazier W.A. , Lacy-Hulbert A. , El Khoury J. , Golenbock D.T. , Moore K.J.
Nat. Immunol.11:155-161(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CD36 AND TLR6;SUBCELLULAR LOCATION
20.

"Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel."
Schmidt M. , Raghavan B. , Mueller V. , Vogl T. , Fejer G. , Tchaptchet S. , Keck S. , Kalis C. , Nielsen P.J. , Galanos C. , Roth J. , Skerra A. , Martin S.F. , Freudenberg M.A. , Goebeler M.
Nat. Immunol.11:814-819(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF HIS-431; HIS-456 AND HIS-458;INVOLVEMENT IN CONTACT ALLERGY TO NICKEL
21.

"MLK4 has negative effect on TLR4 signaling."
Seit-Nebi A. , Cheng W. , Xu H. , Han J.
Cell. Mol. Immunol.9:27-33(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MLK4
22.

"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran."
Kim H.M. , Park B.S. , Kim J.-I. , Kim S.E. , Lee J. , Oh S.C. , Enkhbayar P. , Matsushima N. , Lee H. , Yoo O.J. , Lee J.-O.
Cell130:906-917(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 27-228;DISULFIDE BONDS;GLYCOSYLATION AT ASN-35; ASN-173 AND ASN-205
23.

"The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex."
Park B.S. , Song D.H. , Kim H.M. , Choi B.-S. , Lee H. , Lee J.-O.
Nature458:1191-1195(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 27-631 IN COMPLEX WITH LY96 AND LIPOPOLYSACCHARIDE;DISULFIDE BONDS;GLYCOSYLATION AT ASN-173; ASN-205; ASN-497 AND ASN-526 AND ASN-575
24.

"Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein."
Han J. , Kim H.J. , Lee S.C. , Hong S. , Park K. , Jeon Y.H. , Kim D. , Cheong H.K. , Kim H.S.
PLoS ONE7:E30929-E30929(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 28-228;GLYCOSYLATION AT ASN-35 AND ASN-173;DISULFIDE BONDS
25.

"Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans."
Smirnova I. , Hamblin M.T. , McBride C. , Beutler B. , Di Rienzo A.
Genetics158:1657-1664(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-188; SER-246; GLY-299; SER-329; ILE-399; LEU-443; LYS-474; HIS-510; ARG-694; HIS-763 AND HIS-834
26.

"Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration."
Zareparsi S. , Buraczynska M. , Branham K.E.H. , Shah S. , Eng D. , Li M. , Pawar H. , Yashar B.M. , Moroi S.E. , Lichter P.R. , Petty H.R. , Richards J.E. , Abecasis G.R. , Elner V.M. , Swaroop A.
Hum. Mol. Genet.14:1449-1455(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-299;ASSOCIATION WITH ARMD SUSCEPTIBILITY

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