To evaluate the prevalence of impaired fasting glucose (IFG) and its relationship with cardiovascular risk factors in Han adolescents aged 13 to 18 years.

Methods:
Step 1: A cross-sectional study was conducted on 3937 Han adolescents. IFG was defined as a fasting glucose of 5.6 to 7.0 mmol/l. Measurements included anthropometric measurements, fasting plasma glucose (FPG), and serum lipids.
Step 2: We identified 60 adolescents with IFG from the IFG group using a random number table, and 60 adolescents with normal fasting glucose (NFG) were matched for age and gender with the random IFG sample. Serum true insulin (TI) was further measured.

Results:
(1) The prevalence of IFG was 3.5% and was similar in boys and girls (3.9% vs. 3.1%, P=.177). The prevalence of IFG in adolescents with a family history of type 2 diabetes (FHD) was higher than in adolescents without FHD (6.3% vs. 2.5%, P=.000).
(2) In logistic regression, the clustering of cardiovascular risk factors among adolescents with IFG was 1.889 (95% CI: 1.125–3.171, P=.016) times compared with adolescents with NFG adjusted by age and gender.
(3) Multiple linear regression analysis using FPG as the dependent variable showed that waist circumference (β=0.003, P=.000) was a significant independent predictor.
(4) In Step 2, the IFG group showed significantly higher levels of lnTI and lnHOMA-IR than the NFG group (Pb.01). FPG was a significant independent predictor for lnTI (β=0.478, P=.000) and lnHOMA-IR (β=0.671, P=.000). Conclusion: We found a high prevalence of IFG in Han adolescents. Genetic susceptibility and abdominal obesity were the main factors causing adolescent IFG. Adolescents with IFG increased the clustering of cardiovascular risk factors.