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The main source of arterial injury includes vascular wall sclerosis, a phenomenon known as arteriosclerosis .The arteriosclerosis increases the risk of cardiovascular disease such as hypertension and atherosclerosis. However, the cause of arterial stiffness is still unknown.

On July 24, Immunity published Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

The article shows that when LYVE-1-expressing macrophages covering the outer wall of healthy arteries are absent, the arteries accumulate a large amount of collagen, which loses elasticity and becomes stiff. Macrophages may be protective umbrellas that protect the arteries from stiffness.

There is an interaction between macrophages and smooth muscle cells(SMCs).TheSMCs are responsible for the production of collagen, and interaction between the two cells can reduce collagen production. The LYVE-1 is essentially responsible for this protection. LYVE-1 binds to hyaluronic acid on the cell surface expressed by smooth muscle cells and is a necessary condition for MMP-9-mediated collagen degradation.

Arteriosclerosis is often associated with aging and precedes cardiovascular diseases such as atherosclerosis and aneurysms. This knowledge should help develop methods to improve the prevention and treatment of existing arterial diseases.

Wuhan EIAab Science Co., Ltd has developed LYVE1 protein, antibody and ELISA kit. Welcome scientific research workers to choose and purchase.

The study found new genes for allergic rhinitis

Posted by star on 2018-08-08 19:39:46

    An international research team recently said that they have discovered 20 new risk genes related to allergic rhinitis, which is expected to find new targets for the prevention and treatment of allergic rhinitis.

    Allergic rhinitis is also known as hay fever. The patient is mainly allergic to pollen, dust mites and animal hair. It is characterized by paroxysmal sneezing, a large amount of nasal discharge, and itchy nose. In severe cases, symptoms such as itchy eyes, stuffy nose, and decreased sense of smell may occur.

    The international research team published Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis in the new issue of the journal Nature Genetics. They collected data of nearly 900,000 people and searched the risk genes associated with allergic rhinitis. It is the genetic difference between patients with allergic rhinitis and healthy people.

    The researchers first compared the genomes of 60,000 patients and 150,000 healthy people in the control group, identifying 42 risk genes associated with allergic rhinitis, some of which have been documented in the literature.

    Subsequently, the researchers compared the genomes of another 60,000 patients and 620,000 healthy people, confirming that 20 previously undiscovered risk genes are associated with allergic rhinitis. The researchers said that the identified risk genes could explain the cause of approximately 8% of allergic rhinitis cases.

    The researchers used the database to further confirm the function of these genes, and found that most of them are related to the immune system, and the risk genes of allergic......

Scientists have discovered a protein that is resistant to heart aging

Posted by star on 2018-08-07 18:56:27


    Recently, an article named Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span was published in the journal AIP. The researchers found that using genetic engineering technology to improve the level of a protein in drosophila can keep its cardiomyocytes viable and have a long lifespan extend. This study provides new clues for exploring the relationship between heart function, metabolism, and longevity.

    This protein called vinculin, helps cells stick together and acts like a mortar for construction. The heart of many animals increases the production of focal adhesion protein during aging, helping to maintain myocardial structure and delay the decline of heart function.

    The researchers developed a drosophila with multiple copies of the focal adhesion protein gene, which increased the production of focal adhesion protein in cardiomyocytes by 50%. The results showed that these transgenic drosophilae were particularly active, exercise-enhancing, and lived for up to 9 weeks, while common drosophila usually only lives for 6 weeks.

    These transgenic drosophilae also metabolizes glucose faster, which means that high levels of focal adhesion protein can increase the body's efficiency in absorbing nutrients. The researchers used toxic chemicals to interfere with the energy supply of cardiomyocytes and found that transgenic drosophila were much more tolerant than normal drosophila.

    The researchers said that they hope that their work in the future will bring about drugs that help humans improve the expression of focal adhesion protein and help treat heart failure.

    Wuhan EIAab Science Co., Ltd has d......

Scientists have discovered a new kidney cancer kinesin

Posted by star on 2018-08-07 01:37:44


    Recently, an article called VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma was published in the journal Science. A potential therapeutic target for kidney cancer with the same genetic variation has been found to be known by scientists to cause excessive blood vessels, which helps to provide nutrition for the tumor. This latest discovery demonstrates a potential new cancer-driven pathway.

    More than 90% of clear cell renal cell carcinoma has a genetic change that leads to the loss of the tumor suppressor gene (VHL). In this new study, the researchers identified a new downstream effect of this genetic change to help promote kidney cancer, and they found that an excessive accumulation of a protein called ZHX2 in these cells contributes to activate other signals that promote cancer growth. These findings suggest that ZHX2 is a potential novel therapeutic target for clear cell renal cell carcinoma.

    Clear cell renal cell carcinoma is one of the most common types of kidney cancer, accounting for approximately 70% of all kidney cancer cases. More than 90% of patients with clear cell renal cell carcinoma has mutations or changes in genes that cause loss of VHL function. When the function of VHL is lost, cells can accumulate signals that trigger blood vessel growth.

    These researchers have developed a screening technique to discover new molecules that may help promote cancer when VHL is lost. This led them to identify kidney cancer cells that lack VHL and usually have more ZHX2. By removing ZHX2 from the laboratory model, they are able to inhibit the growth, infiltration, and spread of cancer cells. In addition, they observed that it is associat......

Apple peel extract can delay the aging process

Posted by star on 2018-08-03 02:01:33


    According to the latest issue of Nature Medicine, researchers of Senolytics improve physical function and increase lifespan in old age have found that the combination of dasatinib (a leukemia drug) and quercetin (a extract from apple skin) can make life in older mice Extended by 36%.

    Aging cells usually appear in the human body in their 60s, but appear earlier in obese or chronically ill patients. These abnormal cells are in a state of decline, but they are not willing to die. Some people think that aging cells themselves can catalyze the aging process.

    The research team proved that this is indeed the case. When the researchers injected small amounts of senescent cells into 6-month-old mice, their speed, endurance, and strength dropped by 20% to 50% in a few weeks, almost the same level as a typical 2-year-old mouse.

    To block the effects of aging cells, the team chose a combination of dasatinib and quercetin because both would interfere with the way aging cells avoid death. When the research team administered a combination of drugs to young mice that were aged by infusion into senescent cells, the physical capacity lost by these mice recovered between 50% and 100% in two weeks.

    When the research team administered drugs to older mice between the ages of 24 and 27 months, the speed, endurance and strength of these mice increased by 30% to 100%, and their remaining life was smaller than those who did not. The mouse is 36% long.

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